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Articles (35)
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A feasibility study of a web-based performance improvement system for substance abuse treatment providers

Robert Forman, Paul Crits-Christoph, Övgü Kaynak, Matt Worley, Donald A. Hantula, Agatha Kulaga, John Rotrosen, Melissa Chu, Robert Gallop, Jennifer Potter, Patrice Muchowski, Kirk Brower, Stephen Str

Journal:

Journal of Substance Abuse Treatment

Année:

2007

Langue:

english

Fichier:

PDF, 188 KB

english, 2007

Drosophila eye color mutants as therapeutic tools for Huntington disease

Green, Edward W., Campesan, Susanna, Breda, Carlo, Sathyasaikumar, Korrapati V., Muchowski, Paul J., Schwarcz, Robert, Kyriacou, Charalambos P., Giorgini, Flaviano

Journal:

Fly

Année:

2012

Langue:

english

Fichier:

PDF, 696 KB

english, 2012

Adaptive and Behavioral Changes in Kynurenine 3-Monooxygenase Knockout Mice: Relevance to Psychotic Disorders

Erhardt, Sophie, Pocivavsek, Ana, Repici, Mariaelena, Liu, Xi-Cong, Imbeault, Sophie, Maddison, Daniel C., Thomas, Marian A.R., Smalley, Joshua L., Larsson, Markus K., Muchowski, Paul J., Giorgini, Fl

Journal:

Biological Psychiatry

Année:

2016

Langue:

english

Fichier:

PDF, 893 KB

english, 2016

Author Correction: Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntingtonâs disease

Aron, Rebecca, Pellegrini, Pasquale, Green, Edward W., Maddison, Daniel C., Opoku-Nsiah, Kwadwo, Osorio Oliviera, Anna, Wong, Jinny S., Daub, Aaron C., Giorgini, Flaviano, Muchowski, Paul, Finkbeiner,

Journal:

Nature Communications

Année:

2020

Langue:

english

Fichier:

PDF, 229 KB

english, 2020

Functional similarities between the small heat shock proteins Mycobacterium tuberculosis HSP 16.3 and human αB-crystallin

Melissa M. Valdez, John I. Clark, Gabrielle J. S. Wu, Paul J. Muchowski

Journal:

FEBS Journal

Année:

2002

Langue:

english

Fichier:

PDF, 342 KB

english, 2002

Chaperone function of mutant versions of αA- and αB-crystallin prepared to pinpoint chaperone binding sites

Barry K. Derham, Martinus A. M. van Boekel, Paul J. Muchowski, John I. Clark, Joseph Horwitz, Henry W. Hepburne-Scott, W. W. de Jong, M. James C. Crabbe, John J. Harding

Journal:

FEBS Journal

Année:

2001

Langue:

english

Fichier:

PDF, 834 KB

english, 2001

Dysfunctional kynurenine pathway metabolism in the R6/2 mouse model of Huntington’s disease

Korrapati V. Sathyasaikumar, Erin K. Stachowski, Laura Amori, Paolo Guidetti, Paul J. Muchowski, Robert Schwarcz

Journal:

Journal of Neurochemistry

Année:

2010

Langue:

english

Fichier:

PDF, 458 KB

english, 2010

A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease

Giorgini, Flaviano, Guidetti, Paolo, Nguyen, QuangVu, Bennett, Simone C, Muchowski, Paul J

Journal:

Nature Genetics

Année:

2005

Langue:

english

Fichier:

PDF, 365 KB

english, 2005

Modulation of neurodegeneration by molecular chaperones

Muchowski, Paul J., Wacker, Jennifer L.

Journal:

Nature Reviews Neuroscience

Année:

2005

Langue:

english

Fichier:

PDF, 1.15 MB

english, 2005

Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer

Wacker, Jennifer L, Zareie, M Hadi, Fong, Hanson, Sarikaya, Mehmet, Muchowski, Paul J

Journal:

Nature Structural and Molecular Biology

Année:

2004

Langue:

english

Fichier:

PDF, 1.09 MB

english, 2004

Molecular genetics approaches in yeast to study amyloid diseases

Tiago Fleming Outeiro, Paul J. Muchowski

Journal:

Journal of Molecular Neuroscience

Année:

2004

Langue:

english

Fichier:

PDF, 370 KB

english, 2004

Making yeast tremble

Michael Y. Sherman, Paul J. Muchowski

Journal:

NeuroMolecular Medicine

Année:

2003

Langue:

english

Fichier:

PDF, 150 KB

english, 2003

Kynurenines in the mammalian brain: when physiology meets pathology

Schwarcz, Robert, Bruno, John P., Muchowski, Paul J., Wu, Hui-Qiu

Journal:

Nature Reviews Neuroscience

Année:

2012

Langue:

english

Fichier:

PDF, 1.07 MB

english, 2012

Five-membered heterocyclic thiones. Part VI. 2-methyl-1,2,3-triazole-4-thiol

Jean-Paul Daris, Joseph M. Muchowski

Journal:

Journal of Heterocyclic Chemistry

Année:

1975

Fichier:

PDF, 138 KB

1975

Expanded Polyglutamine-Binding Peptoid as a Novel Therapeutic Agent for Treatment of Huntington's Disease

Xuesong Chen, Jun Wu, Yuan Luo, Xia Liang, Charlene Supnet, Mee Whi Kim, Gregor P. Lotz, Guocheng Yang, Paul J. Muchowski, Thomas Kodadek, Ilya Bezprozvanny

Journal:

Chemistry & Biology

Année:

2011

Langue:

english

Fichier:

PDF, 1.40 MB

english, 2011

The Kynurenine Pathway Modulates Neurodegeneration in a Drosophila Model of Huntington's Disease

Susanna Campesan, Edward W. Green, Carlo Breda, Korrapati V. Sathyasaikumar, Paul J. Muchowski, Robert Schwarcz, Charalambos P. Kyriacou, Flaviano Giorgini

Journal:

Current Biology

Année:

2011

Langue:

english

Fichier:

PDF, 734 KB

english, 2011

Polyglutamine Dances the Conformational Cha-Cha-Cha

Jason Miller, Earl Rutenber, Paul J. Muchowski

Journal:

Structure

Année:

2009

Langue:

english

Fichier:

PDF, 165 KB

english, 2009

Small heat-shock proteins and their potential role in human disease

John I Clark, Paul J Muchowski

Journal:

Current Opinion in Structural Biology

Année:

2000

Langue:

english

Fichier:

PDF, 185 KB

english, 2000

Disruption of theSparcLocus in Mice Alters the Differentiation of Lenticular Epithelial Cells and Leads to Cataract Formation

JAMES A. BASSUK, TED BIRKEBAK, JUSTIN D. ROTHMIER, JUDY M. CLARK, AMY BRADSHAW, PAUL J. MUCHOWSKI, CHIN C. HOWE, JOHN I. CLARK, E.HELENE SAGE

Journal:

Experimental Eye Research

Année:

1999

Langue:

english

Fichier:

PDF, 510 KB

english, 1999

Site-directed mutations within the core “α-crystallin” domain of the small heat-shock protein, human αB-crystallin, decrease molecular chaperone functions

Paul J Muchowski, Gabrielle J.S Wu, Jack J.N Liang, Elinor T Adman, John I Clark

Journal:

Journal of Molecular Biology

Année:

1999

Langue:

english

Fichier:

PDF, 891 KB

english, 1999

Of mice, rats and men: Revisiting the quinolinic acid hypothesis of Huntington's disease

Robert Schwarcz, Paolo Guidetti, Korrapati V. Sathyasaikumar, Paul J. Muchowski

Journal:

Progress in Neurobiology

Année:

2010

Langue:

english

Fichier:

PDF, 1.02 MB

english, 2010

Protein Misfolding, Amyloid Formation, and Neurodegeneration: A Critical Role for Molecular Chaperones?

Paul J. Muchowski

Journal:

Neuron

Année:

2002

Langue:

english

Fichier:

PDF, 79 KB

english, 2002

P1-051: Enhancing Aβ fibrillogenesis increases plaque load but decreases behavioral deficits in human amyloid precursor protein transgenic mice

Irene H. Cheng, Kimberley Scearce-Levie, Jorge P. Palop, Justin Legleiter, Jukka Puoliva, Nga Bien-Ly, Fengrong Yan, Paul Muchowski, Lennart Mucke

Journal:

Alzheimer's & Dementia

Année:

2006

Langue:

english

Fichier:

PDF, 60 KB

english, 2006

Genetic screens in yeast to identify modifiers of beta-amyloid-induced toxicity

Angela M. Sia, Paul J. Muchowski

Journal:

Alzheimer's & Dementia

Année:

2009

Langue:

english

Fichier:

PDF, 42 KB

english, 2009

Synthesis, antiinflammatory and analgesic activity of 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids and related compounds

Muchowski, Joseph M., Unger, Stefan H., Ackrell, Jack, Cheung, Paul, Cook, James, Gallegra, Pascuale, Halpern, Otto, Koehler, Richard, Kluge, Arthur F.

Journal:

Journal of Medicinal Chemistry

Année:

1985

Langue:

english

Fichier:

PDF, 1.68 MB

english, 1985

Downregulation of cannabinoid receptor 1 from neuropeptide Y interneurons in the basal ganglia of patients with Huntington's disease and mouse models

Horne, Eric A., Coy, Jonathan, Swinney, Katie, Fung, Susan, Cherry, Allison E. T., Marrs, William R., Naydenov, Alipi V., Lin, Yi Hsing, Sun, Xiaocui, Dirk Keene, C., Grouzmann, Eric, Muchowski, Paul,

Journal:

European Journal of Neuroscience

Année:

2013

Langue:

english

Fichier:

PDF, 5.96 MB

english, 2013

Mutant Huntingtin Fragments Form Oligomers in a Polyglutamine Length-Dependent Manner

Legleiter, Justin, Muchowski, Paul J.

Journal:

Biophysical Journal

Année:

2010

Langue:

english

Fichier:

PDF, 40 KB

english, 2010

An inhibitor of kynurenine 3-monooxygenase is neuroprotective in a mouse model of Alzheimer's disease

Zwilling, Daniel, Truong, Jennifer, Andrews-Zwilling, Yaisa, Hsieh, Eric, Louie, Jamie, Huang, Yadong, Muchowski, Joseph M., Masliah, Eliezer, Schwarcz, Robert, Muchowski, Paul J.

Journal:

Alzheimer's & Dementia

Année:

2010

Langue:

english

Fichier:

PDF, 40 KB

english, 2010

ATP-Enhanced Molecular Chaperone Functions of the Small Heat Shock Protein Human α B Crystallin

Paul J. Muchowski and John I. Clark

Journal:

Proceedings of the National Academy of Sciences

Année:

1998

Langue:

english

Fichier:

PDF, 1.40 MB

english, 1998

Connecting the dots in Huntington's disease with protein interaction networks

Flaviano Giorgini,Paul J Muchowski

Journal:

Genome Biology

Année:

2005

Langue:

english

Fichier:

PDF, 97 KB

english, 2005

Accelerating Amyloid-β Fibrillization Reduces Oligomer Levels and Functional Deficits in Alzheimer Disease Mouse Models

Cheng, Irene H., Scearce-Levie, Kimberly, Legleiter, Justin, Palop, Jorge J., Gerstein, Hilary, Bien-Ly, Nga, Puoliväli, Jukka, Lesné, Sylvain, Ashe, Karen H., Muchowski, Paul J., Mucke, Lennart

Journal:

Journal of Biological Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 1.28 MB

english, 2007

Tryptophan 2,3-Dioxygenase and Indoleamine 2,3-Dioxygenase 1 Make Separate, Tissue-Specific Contributions to Basal and Inflammation-Induced Kynurenine Pathway Metabolism in Mice

Larkin, Paul B., Sathyasaikumar, Korrapati V., Notarangelo, Francesca M., Funakoshi, Hiroshi, Nakamura, Toshikazu, Schwarcz, Robert, Muchowski, Paul J.

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Année:

2016

Langue:

english

Fichier:

PDF, 520 KB

english, 2016

N-Terminal Fragments of Huntingtin Longer than Residue 170 form Visible Aggregates Independently to Polyglutamine Expansion

Chen, Moore Z., Mok, Sue-Ann, Ormsby, Angelique R., Muchowski, Paul J., Hatters, Danny M.

Journal:

Journal of Huntington's Disease

Année:

2017

Langue:

english

Fichier:

PDF, 2.74 MB

english, 2017

Genetic Manipulation of Palmitoylethanolamide Production and Inactivation in Saccharomyces cerevisiae

Muccioli, Giulio G., Sia, Angela, Muchowski, Paul J., Stella, Nephi, Cobine, Paul

Journal:

PLoS ONE

Année:

2009

Langue:

english

Fichier:

PDF, 396 KB

english, 2009

Publisher Correction: Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntingtonâs disease

Aron, Rebecca, Pellegrini, Pasquale, Green, Edward W., Maddison, Daniel C., Opoku-Nsiah, Kwadwo, Oliveira, Anna Osorio, Wong, Jinny S., Daub, Aaron C., Giorgini, Flaviano, Muchowski, Paul, Finkbeiner,

Journal:

Nature Communications

Année:

2020

Fichier:

PDF, 253 KB

2020